LPS is the major component of the outer membrane of Gram-negative bacteria, contributing greatly to the structural integrity of the bacteria, and protecting the membrane from certain kinds of chemical attack. : 84 Subsequent work showed that release of LPS from gram negative microbes does not necessarily require the destruction of the bacterial cell wall, but rather, LPS is secreted as part of the normal physiological activity of membrane vesicle trafficking in the form of bacterial outer membrane vesicles (OMVs), which may also contain other virulence factors and proteins. The toxic activity of LPS was first discovered and termed endotoxin by Richard Friedrich Johannes Pfeiffer, who distinguished between exotoxins, which he classified as a toxin that is released by bacteria into the surrounding environment, and endotoxins, which he considered to be a toxin kept 'within' the bacterial cell and released only after destruction of the bacterial cell wall.

9 Laboratory research and biotechnology production systems.

7.3 Non-canonical pathways of LPS recognition.

7.2 Effect of variability on immune response.

7 Biological effects on hosts infected with Gram-negative bacteria.

Little do you know lps